The fixture comes just days after the two teams met in the third round of the FA Cup, with Ralf Rangnick’s side holding on to a 1-0 victory after Scott McTominay stuck early.
After a tumultuous first half of the season, United entered the weekend six points adrift of the top four, although Rangnick’s side do also have two games in hand.
Villa have been impressive since Steven Gerrard took charge but are still languishing in 14th in the table with their initial target of securing European football now looking obsolete. Here is everything you need to know:
When is it and what time is kick-off?
The match will get underway at 5.30pm GMT at Villa Park on Saturday 15 January.
How can I watch it online and on TV?
The match will be broadcast live on Sky Sports Main Event and Sky Sports Premier League.
If you’re not a Sky customer you can grab a NOWTV Day Pass here to watch without a subscription.
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What is the team news?
Marvelous Nakamba and Leon Bailey are ruled out due to injury while John McGinn is suspended after picking up five yellow cards this season. Bertrand Traore is away at the African Cup of Nations.
Scott McTominay and Luke Shaw are also both suspended after picking up five yellow cards. Paul Pogba remains out while Anthony Martial is recovering from a knee injury. Eric Bailly is away at the African Cup of Nations.
Aston Villa: Martinez; Cash, Konsa, Mings, Digne; Ramsey, Luiz, Sanson; Buendia, Coutinho, Watkins
Manchester United: De Gea; Wan-Bissaka, Varane, Maguire, Telles; Fred, Matic; Greenwood, Fernandes; Ronaldo, Cavani
Aston Villa – 21/10
Draw – 5/2
Manchester United – 6/5
Aston Villa will be desperate to respond after defeat against United in the FA Cup and will benefit from being on home turf. The arrivals of Digne and Coutinho will boost the squad and it is likely to be a close and hard-fought encounter. Not for the first time this season, though, Ronald might just pop up with a late winner. Aston Villa 1-2 Manchester United.